rna caps การใช้

• Cellular RNA cap structures are formed via the action of an RNA triphosphatase, with guanylyltransferase, N7-methyltransferase and 22-O methyltransferase.
• Cellular RNA cap structures are formed with the action of an RNA triphosphatase, with guanylyltransferase, N7-methyltransferase and 22-O methyltransferase.
• Substrates hydrolysed by Nudix enzymes comprise a wide range of organic pyrophosphates, including nucleoside di-and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity.
• It uses the helicase ATP hydrolysis site to remove the ?-phosphate from the 52 end of the RNA . The N-terminal domain of the non-structural protein 5 ( NS5 ) has both the N7-methyltransferase and guanylyltransferase activities necessary for forming mature RNA cap structures.